The endoplasmic reticulum (ER) uses various mechanisms to ensure that only properly folded proteins enter the secretory pathway. For proteins that oligomerize in the ER, the proper tertiary and quaternary structures must be achieved before their release. Although some proteins fold before oligomerization, others initiate oligomerization cotranslationally. Here, we discuss these different strategies and some of the unique problems they present for the ER quality control system. One mechanism used by the ER is thiol retention. Thiol retention operates by monitoring (...) the redox state of specific cysteine residue(s) and was discovered in studies on the assembly of IgM, a complex oligomeric glycoprotein. This system is also involved in retaining other unassembled proteins in the ER. Mutations that result in uneven numbers of cysteine residues can subject yet other proteins to thiol retention, altering their oligomerization status and function. The implications of these results on the effects of thiol retention on protein function and cell fate are discussed. BioEssays 20:546–554, 1998. © 1998 John Wiley & Sons Inc. (shrink)

Buddhist Inscriptions of Andhradesa. B.S.L. Hanumantha Rao, N. S. Ramachandra Murthy, B. Subrahmanyam, E. Sivanagi Reddy. Ananda Buddha Vihara Trust, Secunderabad 1998. xi, 278 pp. Rs 500.

Some propositional attitude verbs require that the complement contain some “subjective predicate”. In terms of the theory proposed by Lasersohn, these verbs would seem to identify the “judge” of the embedded proposition with the matrix subject, and there have been suggestions in this direction. I show that it is possible to analyze these verbs as setting the judge and doing nothing more; then according to whether a judge index or a judge argument is assumed, unless the complement contains a subjective (...) predicate, the whole matrix is redundant or there is a type conflict. I further show that certain clear facts argue for assuming a judge argument which can be filled by a contextually salient entity–or by the subject of a subjective attitude verb. (shrink)

The merit of Plato’s Laws remains largely untapped by those seeking genuinely collaborative models of the doctor–patient tie as alternatives to paternalism and autonomy. A persistent difficulty confronting proposed alternatives has been surpassing the notion of pronounced intellectual and values asymmetry favoring the doctor. Having discussed two prominent proposals, both of which evince marked paternalism, I argue that reflection on Plato yields four criteria that a genuinely collaborative model must meet and suggest how the Laws addresses them. In the process, (...) the Laws’ doctor–patient tie is shown to be far more nuanced than interpreters have previously observed. Although Plato’s account will not solve our own quandaries, it illustrates how one might retain asymmetry of a kind without capitulating to familiar oppositional modalities. Through this account, I hope to show that the Laws merits fuller inclusion in contemporary discussions than it has heretofore received. (shrink)

Two main methods for analysing de re readings of definite descriptions in intensional contexts coexist: that of evaluating the description in the actual world, whether by means of scope, actuality operators, or non-local world binding, and that of substituting another description, usually one expressing a salient or ‘vivid’ acquaintance relation to an attitude holder, prior to evaluation. Recent work on so-called descriptive indexicals suggests that contrary to common assumptions, both methods are needed, for different ends. This paper aims to show (...) that there is indeed a division of labour between the two methods of analysis and to identify criteria for choosing among alternative ways to model the second, substitutional method. (shrink)

One of the most interesting phenomena of our religious-political life is the considerable difference in attitude toward religion between the popular masses and the political elite. In our survey of public opinion, the respondents had to express their attitude to two alternative statements: "There are national, traditional religions in our country. They should have more rights than representatives of religions that are new to our country "; and "All religions should have absolutely equal rights." Only 9 percent agreed with the (...) first statement, while the vast majority agreed with the second. Even among the Orthodox, adherents of the Moscow patriarchy, only 13 percent were supporters of special patronage by the state for the traditional religions, while those who advocated an equality of religion made up 69 percent. Thus, the idea of a state church is alien to the contemporary popular consciousness. The evolution of mass consciousness is toward an even greater amorphousness and indefiniteness with regard to religion and further away from the idea of a national, state church. The data confirming this have already been presented. Let me just recall that the percentage of persons who approved of the church's participation in political life decreased from 74 percent to 48 percent from 1990 to 1991. (shrink)

How questions are understudied in philosophy and linguistics. They can be answered in very different ways, some of which are poorly understood. Jaworski identifies several types: ‘manner’, ‘method, means or mechanism’, ‘cognitive resolution’, and develops a logic designed to enable us to distinguish among them. Some key questions remain open, however, in particular, whether these distinctions derive from an ambiguity in how, from differences in the logical structure of the question or from contextual underspecification. Arguing from two classes of responses, (...) adverbs and by gerunds, I give the answer that the logical structure of the question is indeed relevant: loosely, manners are adjuncts but methods are arguments. (shrink)

The type of mood or tense marking that causes counterfactuality inferences—as figuring prominently, but far from exclusively, in counterfactual conditionals—has not yet received a comprehensive and compositional analysis. Focusing on four languages, the paper presents under-appreciated facts and a novel theory where the mood serves to activate alternatives to modal operators, particularly one: the identity operator, often giving rise to counterfactual implicatures.

Pid syhnaturoi︠u︡ Sofiï -- Zapyty filosofsʹkykh smysliv.

Монография предназначена студентам старших курсов высших учебных заведений факультета иностранных языков, аспирантам и преподавателям.

Explains the intersubjective nature of the self and the function of role taking in the development of the personal level of intersubjectivity out of primordial, pre-personal sociality or corporeal intersubjectivity of the lived body. Pragmatic philosophy of George Herbert Mead; Existential-phenomenology of Maurice Merleau-Ponty; Fundamental and pervasive rapport; More.

The capacity-building strategy used by a US-based research organisation, the Pacific Institute for Research and Evaluation , to strengthen the system for the protection of human research subjects and the infrastructure of its international collaborating partner, the University of Liberia, are discussed. To conduct the much-needed biomedical and social science-based research-related activities in the future, this partnership is expected by PIRE to gradually evolve over time to strengthen the capacity of the local investigators and administrators of the University of Liberia. (...) Accordingly, a unique opportunity to share technology and resources with a post-conflict, resource-constrained country is created by this partnership. This capacity-building model to strengthen the protection of human subjects in research can also be replicated in similar resource-constrained international settings and, accordingly, our experiences and limitations are shared in this paper. (shrink)

Film can be a significant way of doing public philosophy. This chapter sketches some essential public features of philosophy by using popular films. Learning to watch popular films as philosophical expressions, on par with books and articles, brings film and philosophy to inform one another and illuminate important areas of overlap. Memento is an especially uncanny film because it begins with the story's ending. Daniel J. Clark's 2018 documentary film Behind the Curve charts the resurgence of flat‐Earth theory in the (...) United States. Its core thesis is that false, avowed belief in flat‐Earth is sustained partly by an irrational weighing of evidence reinforced by various social, psychological, and economic benefits that come from holding the belief. We gain insight into a classic mechanism of motivated reasoning from Tony Kaye's film American History X, a fictional exploration of the rise of white supremacist ideology in US white working‐class neighborhoods. (shrink)

Questions of dialectical logic are currently of great importance in Marxist-Leninist philosophy. However, most of the logicians in our country are working on problems of mathematical logic, which is not a philosophical science. The axiomatic method is basic to mathematical logic, and its basic concept is the notion of functional dependence. Logic, as a philosophical discipline, has always studied and should study the relationship between antecedent and consequent, which is concerned not with functional dependence, not with an external connection, but (...) with an internal logical necessity. To reduce the logical relationship to functional dependence means to abolish the discipline of logic. No philosophical system, no philosophical work, has been, nor could be, constructed on the basis of mathematical logic. (shrink)